FREIE-WELT.EU NEWS: 06.05.21 - Nachrichten App Freie Welt für Android 05.05.21 - Progressive Web App (Cron-Fehler) - 28.04.21 - NEUER SERVER // 26.04.21 - Freie Welt als Elektron App zum Download (Windows only)


❈ Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Wissen science.sciencemag.org

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are no approved vaccines or therapeutics for treating COVID-19. Here we report a humanized monoclonal antibody, H014, that efficiently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at nanomolar concentrations by engaging the spike (S) receptor binding domain (RBD). H014 administration reduced SARS-CoV-2 titers in infected lungs and prevented pulmonary pathology in a human angiotensin-converting enzyme 2 mouse model. Cryo–electron microscopy characterization of the SARS-CoV-2 S trimer in complex with the H014 Fab fragment unveiled a previously uncharacterized conformational epitope, which was only accessible when the RBD was in an open conformation. Biochemical, cellular, virological, and structural studies demonstrated that H014 prevents attachment of SARS-CoV-2 to its host cell receptors. Epitope analysis of available neutralizing antibodies against SARS-CoV and SARS-CoV-2 uncovered broad cross-protective epitopes. Our results highlight a key role for antibody-based therapeutic interventions in the treatment of COVID-19.

...


Kompletten Artikel lesen (externe Quelle: http://science.sciencemag.org/cgi/content/short/369/6510/1505?rss=1)

Zur Freie Welt Nachrichtenportal Startseite

➤ Weitere Beiträge von Freie-Welt.eu

European Parliament to Frontex: drop the demand for legal fees

vom 1424.27 Punkte
In an unprecedented move, the European Parliament has called on Frontex, the EU’s border police force, to withdraw its demand for legal fees - and to refrain from doing it again in the future. Fabrice Leggeri, Frontex Executive Director Foto-Credit: Frontex Last month, the EU General Court ruled we would have to pay Frontex € 10,520 in legal fees after we had lost our lawsuit against the EU border police force for information on their operations in the Central Mediterranean. The Court’s decision came after Frontex had taken us to court seeking to force us to pay twice as much: € 23,700. Now, the European Parliament has told Frontex it should not claim the money, calling on the agency to drop its demand for legal fees - for our case, and for any other transparency lawsuits in the future. This demand had been previously put forward by 44 human rights NGOs and more than 87,000 citizens. The Parliament states that “charging civil society with excessively high legal fees has a chilling effect on civil society’s access to justice”. It says that it is “deeply concerned” with Frontex’s decision to demand € 23,700 from us and calls on Frontex to “withdraw its demand for recov

Redebeiträge von der Kundgebung „Solidarität mit den emanzipatorischen kämpfen in China" in Leipzig vom 17.04.2021

vom 857.74 Punkte
              1. Redebeitrag: Initiative: 左回声Left Echo Homepage: https://zuohuishengleftecho.org/ Twitter: @leftechoLE Hallo und willkommen zu unserer heutigen Kundgebung unter dem Motto "Picking quarrels und provoking trouble -- Solidarität m

Zweite Berliner Libyen-Konferenz

vom 823.99 Punkte
CONFERENCE CONCLUSIONS Today, at the invitation of German Foreign Minister Maas and United Nations Secretary-General Guterres, High Representatives of the Governments of Algeria, China, the Democratic Republic of the Congo (AU Chair), Egypt, France, Ger

ASIA-EUROPE MEETING (ASEM) STATEMENT ON CORONAVIRUS DISEASE (COVID-19) BY THE FOREIGN MINISTERS OF CAMBODIA AS HOST NATION OF THE 13th ASEM SUMMIT, THE EU AND GERMANY AS REGIONAL COORDINATORS OF THE EUROPEAN GROUP, SINGAPORE AS THE REGIONAL COORDINAT

vom 497.3 Punkte
We, the Foreign Ministers of the Host of the 13th Asia-Europe Meeting (ASEM) Summit and the ASEM Regional Coordinators, in consultation with ASEM partners2, express deep concern over the COVID-19 pandemic, which is an unparalleled global health

Joint Statement of the 5th German-Palestinian Steering Committee

vom 459.15 Punkte
Following up on previous meetings of the Committee as well as numerous bilateral encounters, such as the visit by President Abbas to Berlin in August 2019 and his exchange with Chancellor Merkel, the German-Palestinian Steering Committee met virtually

Joint statement by the Ministers for Foreign Affairs of the Weimar Triangle (France, Germany and Poland) - Jean-Yves Le Drian, Heiko Maas and Zbigniew Rau

vom 442.06 Punkte
At a time when the European Union's neighbourhood is affected by the emergence or continuation of serious crises and conflicts, and the basic rules of international law are being violated, we, the Ministers of Foreign Affairs of France, Germany and

Keynote von Staatsminister Niels Annen anlässlich der 2019 Hamburg (Insecurity) Sessions

vom 401.82 Punkte
-- es gilt das gesprochene Wort -- We are currently seeing a tectonic shift in the world’s geopolitical and economic make-up that is threatening the very foundation on which the EU’s foreign and security policy has been built. Instability

We need strong global cooperation and solidarity to fight COVID-19

vom 364.84 Punkte
The COVID-19 pandemic is a wake-up call for multilateralism. Trying to cope with the immediate devastating effects of the virus, nations have turned toward imposing unprecedented executive measures, including closing borders. However, a virus knows

Rede von Staatsminister Annen beim Empfang von Foreign Secretary Vijay Gokhale anlässlich des Raisina-Dialogs 2020

vom 306.34 Punkte
Thank you, Foreign Secretary Gokhale, for inviting me to speak to you today and for your kind words of introduction. As we usher in a new decade, the 2020s, one thing has become crystal clear once again: peace cannot be taken for granted. The devel

Covid-19 und der Katastrophenkapitalismus

vom 275.74 Punkte
Covid-19 und der Katastrophenkapitalismus Internationale Warenketten und ökologisch-epidemiologisch-ökonomische Krisen Gerd Wiegel 4 September, 2020 - 16:26 John Bellamy

Chair’s Statement: Friends of Sudan Meeting, Berlin (virtual), 28 January 2021

vom 258.6 Punkte
The meeting was opened by Mr. Miguel Berger, State Secretary of the Federal Foreign Office for Germany, and by Dr. Omer Manis, Minister of Cabinet Affairs for Sudan. Dr. Hiba Mohamed Ali Ahmed, Acting Minister of Finance and Economic Planning for S

Ministertreffen der internationalen Anti-IS-Koalition – Gemeinsame Erklärung

vom 258.6 Punkte
The Ministers of the Global Coalition to Defeat Daesh/ISIS, reconvening in-person after two years, met today in Rome at the invitation of Italian Minister of Foreign Affairs and International Cooperation Luigi Di Maio and U.S. Secretary

Kommentare ber Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody