Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

vom 14.03.2019 um 18:40 Uhr 313.07 Punkte
Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing wi

Balancing volumetric and gravimetric uptake in highly porous materials for clean energy

vom 16.04.2020 um 19:40 Uhr 299.03 Punkte
A huge challenge facing scientists is the development of adsorbent materials that exhibit ultrahigh porosity but maintain balance between gravimetric and volumetric surface areas for the onboard storage of hydrogen and methane gas—alternatives to

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase

vom 10.01.2019 um 19:37 Uhr 288.98 Punkte
N6-methyladenosine (m6A), a major modification of messenger RNAs (mRNAs), plays critical roles in RNA metabolism and function. In addition to the internal m6A, N6, 2'-O-dimethyladenosine (m6Am) is present at the transcription start nucleotide of capped m

Characterization of hydrogen-substituted silylium ions in the condensed phase

vom 11.07.2019 um 19:40 Uhr 264.9 Punkte
Hydrogen-substituted silylium ions are long-sought reactive species. We report a protolysis strategy that chemoselectively cleaves either an Si–C(sp2) or an Si–H bond using a carborane acid to access the full series of [CHB11H5Br6]–-stabilized R2SiH+, RSiH2+, and SiH3+ cations, where bulky tert-butyl

Atmospheric 14C/12C changes during the last glacial period from Hulu Cave

vom 13.12.2018 um 19:38 Uhr 240.82 Punkte
Paired measurements of 14C/12C and 230Th ages from two Hulu Cave stalagmites complete a precise record of atmospheric 14C covering the full range of the 14C dating method (~54,000 years). Over the last glacial period, atmospheric 14C/12C ranges from

Abschließende Beratungen ohne Aussprache

vom 10.06.2021 um 08:15 Uhr 217.9 Punkte
Ohne Aussprache entscheidet der Bundestag am Donnerstag, 10. Juni 2021, über eine Reihe von Vorlagen: Doppelbesteuerungsabkommen mit Irland: Die Abgeordneten stimmen über einen Entwurf der Bundesregierung für ein Gesetz zum Protokoll vom 19. Januar

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

vom 07.03.2019 um 19:41 Uhr 216.74 Punkte
Nicotinamide adenine dinucleotide phosphate (NADP+) is essential for producing NADPH, the primary cofactor for reductive metabolism. We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)–Akt pathway induces acute synthes

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

vom 30.01.2020 um 19:40 Uhr 216.74 Punkte
N6-methyladenosine (m6A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the m6A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases ch

Structural basis for transcriptional start site control of HIV-1 RNA fate

vom 23.04.2020 um 19:41 Uhr 216.74 Punkte
Heterogeneous transcriptional start site usage by HIV-1 produces 5'-capped RNAs beginning with one, two, or three 5'-guanosines (Cap1G, Cap2G, or Cap3G, respectively) that are either selected for packaging as genomes (Cap1G) or retained in cells as tra

Online Geld verdienen – so geht’s

vom 07.03.2023 um 14:00 Uhr 213.81 Punkte
Online schnell Geld verdienen. In Heimarbeit. Wir zeigen viele Möglichkeiten, wie Sie von zu Hause aus im Internet Geld verdienen. Viele Tipps für mehr Geld im Jahr 2023. Gebrauchte Produkte verkaufen bei Ebay, Amazon und Co. Um Ware im Intern

Illegalen Import über Online-Marktplätze stoppen

vom 27.11.2020 um 10:08 Uhr 207.05 Punkte
Illegalen Import über Online-Marktplätze stoppen Vanessa Lippert 27.11.2020 | 10:08 Uhr Offener Brief von Umwelt-, Ver

WDFY4 is required for cross-presentation in response to viral and tumor antigens

vom 08.11.2018 um 19:37 Uhr 192.66 Punkte
During the process of cross-presentation, viral or tumor-derived antigens are presented to CD8+ T cells by Batf3-dependent CD8α+/XCR1+ classical dendritic cells (cDC1s). We designed a functional CRISPR screen for previously unknown regulators o